InterPAD - DETAILS

(E)-cinnamic acid, 2-(14)C-labeled cpd, cinnamic acid, cinnamic acid, (trans)-(E)-isomer, cinnamic acid, (Z)-isomer, cinnamic acid, 1-(13)C-labeled cpd, cinnamic acid, 1-14C-labeled cpd, cinnamic acid, 13C-labeled cpd, cinnamic acid, 14C-labeled cpd, cinnamic acid, 14C-labeled cpd (E)-isomer, cinnamic acid, 2-(13)C-labeled cpd, cinnamic acid, 2-(14)C-labeled cpd, cinnamic acid, 3-(14)C-labeled cpd, cinnamic acid, 3H-labeled cpd (E)-isomer, cinnamic acid, 3H-labeled cpd (Z)-isomer, cinnamic acid, ion(1-), cinnamic acid, ion(1-)-(E)-isomer, cinnamic acid, nickel (+2) salt, cinnamic acid, potassium salt, cinnamic acid, radical ion(1-), cinnamic acid, sodium salt, cinnamic acid, sodium salt(E)-isomer, cinnamic acid, sodium salt(Z)-isomer, cinnamic acid, zinc salt(E)-isomer, cis-cinnamic acid, E-cinnamic acid, E-Z cinnamic acid, sodium cinnamate, trans-cinnamic acid, tritium labeled (E)-cinnamic acid, tritium labeled (Z)-cinnamic acid

No.	Title	Href
1	Ethacrynic acid and cinnamic acid combination exhibits selective anticancer effects on K562 chronic myeloid leukemia cells. Mol Biol Rep. 2022 Aug;49(8):7521-7530. doi: 10.1007/s11033-022-07560-5.	`Click`

No.

Title

Href

Ethacrynic acid and cinnamic acid combination exhibits selective anticancer effects on K562 chronic myeloid leukemia cells. Mol Biol Rep. 2022 Aug;49(8):7521-7530. doi: 10.1007/s11033-022-07560-5.

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Name	Cinnamic acid
PubChem CID	444539
Molecular Weight	148.16g/mol
Synonyms	(E)-cinnamic acid, 2-(14)C-labeled cpd, cinnamic acid, cinnamic acid, (trans)-(E)-isomer, cinnamic acid, (Z)-isomer, cinnamic acid, 1-(13)C-labeled cpd, cinnamic acid, 1-14C-labeled cpd, cinnamic acid, 13C-labeled cpd, cinnamic acid, 14C-labeled cpd, cinnamic acid, 14C-labeled cpd (E)-isomer, cinnamic acid, 2-(13)C-labeled cpd, cinnamic acid, 2-(14)C-labeled cpd, cinnamic acid, 3-(14)C-labeled cpd, cinnamic acid, 3H-labeled cpd (E)-isomer, cinnamic acid, 3H-labeled cpd (Z)-isomer, cinnamic acid, ion(1-), cinnamic acid, ion(1-)-(E)-isomer, cinnamic acid, nickel (+2) salt, cinnamic acid, potassium salt, cinnamic acid, radical ion(1-), cinnamic acid, sodium salt, cinnamic acid, sodium salt(E)-isomer, cinnamic acid, sodium salt(Z)-isomer, cinnamic acid, zinc salt(E)-isomer, cis-cinnamic acid, E-cinnamic acid, E-Z cinnamic acid, sodium cinnamate, trans-cinnamic acid, tritium labeled (E)-cinnamic acid, tritium labeled (Z)-cinnamic acid
Formula	C₉H₈O₂
SMILES	C1=CC=C(C=C1)C=CC(=O)O
InChI	1S/C9H8O2/c10-9(11)7-6-8-4-2-1-3-5-8/h1-7H,(H,10,11)/b7-6+
InChIKey	WBYWAXJHAXSJNI-VOTSOKGWSA-N
CAS Number	140-10-3
ChEMBL ID	CHEMBL27246
ChEBI ID	CHEBI:27386
Drug Bank ID	DB18313
KEGG ID	C10438
Toxicity	Organism	Test Type	Route(Dose)
	rat	LD50	intraperitoneal(165 mg/kg)
	mouse	LD50	intraperitoneal(254 mg/kg)
	rat	LD50	oral(322 mg/kg)
Structure			Download 2D MOL 3D MOL

Chineses Pinyin	RouGui
Use Part	Bark
Flavor	Pungent; Sweet
Meridian Tropism	Kidney; Spleen; Heart; Liver
Species	>Kingdom: Viridiplantae 　-->Phylum: Streptophyta 　　-->Class: Equisetopsida 　　　-->Order: Laurales 　　　　-->Family: Lauraceae 　　　　　-->Genus: Cinnamomum 　　　　　　-->Species: Cinnamomum aromaticum

Pair Name	Cinnamic acid, Ethacrynic acid
Partner Name	Ethacrynic acid
Disease Info	[ICD-11: 2B33.2]	Chronic myeloid leukemia		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
In Vitro Model	K-562	Blast phase chronic myelogenous leukemia	Homo sapiens (Human)	CVCL_0004
Result	Ethacrynic acid and cinnamic acid combination exhibits selective anticancer effects on K562 chronic myeloid leukemia cells